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Pitstop 2
CAS No. 1419320-73-2
Pitstop 2 ( —— )
产品货号. M23573 CAS No. 1419320-73-2
Pitstop 2 是一种网格蛋白抑制剂，通过与网格蛋白末端结构域结合来抑制网格蛋白介导的内吞作用 (CME)。它具有抗癌研究的潜力。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥389 | 有现货 |
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| 5MG | ￥648 | 有现货 |
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| 10MG | ￥1126 | 有现货 |
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| 25MG | ￥2341 | 有现货 |
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| 50MG | ￥3686 | 有现货 |
|
| 100MG | ￥5443 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Pitstop 2
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Pitstop 2 是一种网格蛋白抑制剂，通过与网格蛋白末端结构域结合来抑制网格蛋白介导的内吞作用 (CME)。它具有抗癌研究的潜力。
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产品描述Pitstop 2 is a inhibitor of clathrin, and inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. It has the potential for anti-cancer research.
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体外实验Pitstop 2 (20-40 μM; 30 min) inhibits the endocytosis of transferrin in J774A.1 macrophages and does not compromise cell viability.Pitstop 2 (20-40 μM; 30 min) does not affect the internalization of cholera toxin B in J774A.1 macrophages.Pitstop 2 (0.001-100 μM; 6 h) inhibits the mitotic spindle and impairs mitotic progression in HeLa cells.Pitstop 2 (1-30 μM; 24 h) induces apoptosis and inhibits cell growth in dividing cancer cells.Pitstop 2 (1-30 μM; 48 h) does not affect the growth and viability of non-tumourigenic NIH3T3 fibroblasts. Cell Viability Assay Cell Line:HeLa cells Concentration:1, 3, 10, 30 μM Incubation Time:24 hours Result:Reduced the total number of viable HeLa cells markedly in a dose-dependent manner.
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体内实验——
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同义词——
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通路Apoptosis
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靶点Apoptosis
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受体Apoptosis
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研究领域——
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适应症——
化学信息
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CAS Number1419320-73-2
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分子量473.36
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分子式C20H13BrN2O3S2
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纯度>98% (HPLC)
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溶解度DMSO : 62.5 mg/mL (132.03 mM; Need ultrasonic)
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SMILESO=S(C1=C2C=CC=CC2=CC=C1)(NC(S/C3=C\C4=CC=C(Br)C=C4)=NC3=O)=O.[(Z)]
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Smith CM, et, al. Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells. Mol Cancer. 2013 Jan 17; 12:4.
产品手册
